Modafinil (Modalert 200), available in brand name of Provigil, is a eugeroic medication used for excessive sleepiness caused by several sleep disorders. Eugeroics also called ‘wakefulness promoting agents’ or ‘wakefulness promoting drugs’. These are a class of medications that endorse wakefulness without producing euphoric effects and with a lower addictive potential. Modafinil is available in brand and generic versions and used both on a prescription basis and off label for its cognitive enhancement properties.
Research is still ongoing regarding the exact mechanism of action of Modafinil. Studies have proved that a lot of monoaminergic effects of Modafinil are a result of its synergistic actions on histamine, norepinephrine, serotonin, dopamine and orexin levels of the CNS. In a study conducted to understand the binding receptors of Modafinil, it was found that Modafinil shows binding affinity towards a number of receptors. Adenosine, Dopamine, GABA, serotonin, angiotensin and vasoactive intestinal peptide are some of the common receptors to which it binds for a synergistic effect.
Apart from these receptors, it affects the epidermal growth factors, calcium channels, chloride channels, and potassium or K+ channels to activate the senses related to alertness and wakefulness at the same time inducing calmness of the mind. Most importantly, the affinity of Modafinil has been noticed with the GABA inhibitory neurotransmitter whose reabsorption is prevented by the binding effects of the drug. This leads to an increase in its extracellular production promoting motor, wakefulness, and alertness effects. In a study conducted to compare the effects of Modafinil and Methamphetamine, it was observed that both increased wakefulness but Modafinil was more effective and did not result in rebound hypersomnolence like Methamphetamine.
Modafinil tablets should be used as prescribed and scheduled by your medical advisor. Dosage is usually prescribed upon the following factors:
Doctors usually begin with a low dosage and as the body begins to adapt to the medicine, they tend to increase the dose.
However, to encapsulate, these are some of the typical dosage schedules prescribed to consumers of Modafinil.
Some of the common side effects associated with the consumption of Modafinil tablets are mentioned down below:
Serious side effects of Modafinil are:
Therefore, upon facing these symptoms, consuming Modafinil should be stopped immediately.
Furthermore, allergic reactions to Modafinil might be rare but not absent. Therefore, if you observe signs of allergic reactions like the development of hives, difficulty in breathing, or swelling of lips, tongue, face, or throat, rush to the nearest medical care immediately.
Modafinil is a Schedule IV prescription drug, therefore there are certain precautions that one should keep in mind while using Modafinil tablets.
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It is not illegal to buy Modafinil in the UK, but it is illegal to resell, unless you are a certified pharmacist.
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Modafinil is usually recommended to be followed according to a fixed schedule as it helps in providing the best results. However, if a patient misses on a dose, it is advised to take it as soon as the patient remembers.
But if it is near the time of the next dose then it is strictly prohibited. Doubling the dose is strictly prohibited as it will lead to overdosing. If you observe symptoms like trouble in breathing or having irregular heartbeat, hallucinations, or restlessness, rush yourself to the nearest medical care immediately.
Also, Modafinil should not be taken near bedtime as it will disrupt the sleep cycle.
Drug interactions change the mechanism of medication or in some cases can even increase the intensity of side effects.
Medications like birth control pills, axitinib, bosutinib, or medicines to treat hepatitis C can affect the working of Modafinil. On the other hand, medicines containing Armodafinil should be avoided as well.
Modafinil is usually recommended for 12 weeks or even less. Due to frequent cases of psychological and physical dependence on the drug, Modafinil is not usually recommended for long-term use. However, in some cases, it might be the only treatment available for ameliorating symptoms of narcolepsy and other sleeping disorders.
Modafinil might not suit some people and therefore does not produce the desired results in some cases.
In that case, patients are advised to use alternatives for Modafinil. Medications like Adderall, Armodafinil, sodium oxybate, amphetamine, or methylphenidate are used then.
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Introduction Defined as disturbances in the circadian cycle affecting the normal sleep time, sleep disorders left untreated can lead to a number of health complications.
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