What is Artvigil?
Artvigil, a generic version of Waklert, is an enantiopure compound of the racemic compound Modafinil. Enantiopure compounds contain only one enantiomer, which increases their purity and makes them last for a longer time period. Artvigil was introduced by the HAB Pharma and is currently a schedule IV medication and is FDA approved.
What is Artvigil used for?
Artvigil has been legally approved to treat cases of excessive daytime sleepiness due to narcolepsy, shift work disorder, and as an adjunctive medication in cases of sleep apnea. Research is ongoing about its adjunctive use in bipolar disorder. Off-label, it is used for cases of ADHD, chronic fatigue syndrome, and major depressive disorder with a few cases of jet lag.
What is the Artvigil mechanism of action?
The exact mechanism of action of Artvigil is still under research, but it exhibits properties similar to that of Modafinil. It binds to the GABA receptors and prevents its reuptake, leading to its increased production. But unlike Modafinil, its effects are of stronger intensity because of its enantiopure quality. Additionally, motor action is not compromised in using the medication.
What is the dosage of Artvigil?
Artvigil is available in tablet form in strength of 150mg.
The dose of Artvigil for patients with narcolepsy or obstructive sleep apnea is 150 mg, taken once daily as a single dose, preferably in the morning.
For shift work sleep disorder, Artvigil 150mg is taken once daily an hour before the start of the shift.
What do Artvigil tablets look like?
Artvigil 150mg round tablets are available in white or off-white color with C engraved on one side and 205 engraved on the other.
100mg tablets are flat oval tablets that come with a white to an off-white hue. The word C has been engraved on one side of the tablet and 215 on the other.
150mg tablets are rounded rectangular white to off white colored with C engraved on one side and 220 on the other.
150mg tablets are oval white to off white colored with C engraved on one side and 225 on the other.
What are the ingredients of Artvigil?
Artvigil is manufactured as a whitish crystalline powder made into tablets as per their strengths. Armodafinil is the active ingredient of the medication. Inactive ingredients consist of croscarmellose sodium, colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone and pregelatinized starch.
How much time does Artvigil take to show its effectiveness?
Artvigil is readily absorbed after oral administration and has been known to show peak plasma concentrations within 2 hours of ingestion. Its effects are noticed faster when taken on an empty stomach than with food. It has a half-life of 12-15 hours and stays in the system for around 15-22 hours, after which it is metabolized and excreted by the liver and kidneys, respectively.
How to buy Artvigil in UK?
Artvigil, a Schedule IV medication, is a controlled drug and not available without a prescription in the UK. You need a physician’s prescription to either obtain the drug from a registered pharmacy or procure the refills from a clinic. You can also order the generic version online to buy Artvigil UK for next-day delivery. Online ordering ensures that you get the drug quickly and easily.
Are there any contraindications of using Artvigil?
Artvigil should not be used in children as its safety and effectiveness in children under 18 is still under research. It should be avoided or used with caution in pregnant and breastfeeding women as it may affect the fetus or infant. It is also contraindicated in people with high blood pressure, ventricular hypertrophy, liver dysfunctions, depression, and other psychiatric disorders.
What are the side effects associated with Artvigil?
Common Armodafinil side effects – Headache, nausea, vomiting, constipation, sweating, loss of appetite, frequent urination, diarrhea, tingling of hands and feet.
Serious Armodafinil side effects – Insomnia, difficulty falling asleep, uncontrollable shaking of a part of the body, peeling of the skin, hallucinations, and suicidal thoughts.
Modafinil versus Artvigil – which is better?
Both Modafinil and Artvigil are wakefulness-promoting drugs that work on the GABA receptors to treat excessive sleepiness cases. While Modafinil is a racemic mixture containing L and S enantiomer, Artvigil contains only one enantiomer, because of which it has a longer half-life. Its effects last for a longer time in comparison to Modafinil with the same tolerance.
What are Artvigil drug interactions?
Artvigil with Oxycodone
Artvigil used concomitantly with Oxycodone may reduce the blood levels of Oxycodone, thus reducing its effectiveness as a pain killer.
Armodafinil with Citalopram
Concomitant use of Citalopram with Artvigil can increase the blood levels of Citalopram and increase the risk of abnormal heart rhythm that can be life-threatening.
Armodafinil with Olaparib
Olaparib is an anti-cancer medication used in the treatment of ovarian cancer. Concomitant use of Artvigil with Olaparib can reduce the levels of Olaparib in the old stream and reduce its anti-cancerous properties.
Artvigil with Esketamine
Esketamine is an antidepressant that can cause transient but significant changes in blood pressure. Using it with Artvigil can further increase the risk.
Can I use Artvigil with alcohol?
Artvigil and alcohol contradict each other’s effects, with Armodafinil leading to wakefulness and alcohol promoting drowsiness. Using the two together can lead to a decrease in the effectiveness of Artvigil. Additionally, driving or operating heavy machinery after using alcohol along with the nootropic medication can impair motor coordination and increase the risk of accidents and falls.
Are there any disease interactions of Artvigil?
Artvigil should not be used by people dealing with cardiovascular and liver dysfunctions as it can lead to irregular ECG changes and delayed metabolism leading to overdosing effects. It should also be avoided in psychiatric complications like bipolar disorders and psychotic disorders as it may exacerbate the behavioral disturbances, manic episodes, and increased complications.
What is the legal status of Artvigil?
Because of its cognitive enhancement properties, it is being used by healthy individuals for increased focus and productivity. This has led to an increase in the misuse of the drug leading the state to declare it a controlled substance. Artvigil is a Schedule IV medication and can be bought only through a physician’s prescription, and it is illegal to procure it without a prescription.