Tapentadol UK : Before Ordering Tapentadol 100mg , All You Need To Know
What is Tapentadol ?
Tapentadol is not a non-addictive alternative to other opioids, even though it is sometimes called “non-addictive.” Long-term use of any opioid can lead to physical dependence and potentially addiction.In clinical trials, Tapentadol has demonstrated effectiveness for treating moderate to severe acute pain, short-term (3 days or less) postoperative pain, and when used with another analgesic, as needed for chronic or cancer-related pain.
Opioid analgesics are substances designed to act on the opioid receptors of the brain to carry out their analgesic effects. What sets Tapentadol apart from conventional opioids is its dual mode of action on the mu-opioid receptor activity and noradrenaline reuptake inhibition, which makes it a safer and more effective treatment option. Tapentadol was introduced in the 1980s and regarded as a derivative of Tramadol, an equally potent metabolite used as a first-generation analgesic drug. Subsequently, it was FDA approved in Europe and almost 80 countries worldwide.
Benefit of Tapentadol Online 100 mg
- It is not addictive when used as prescribed by your doctor, but you may still get withdrawal symptoms if you stop taking it suddenly or decrease the dose without talking to your doctor first. Therefore, it’s important that you do not stop taking this medicine unless advised by your doctor.
- Tapentadol sustained release is a licensed and branded drug for ongoing management of moderate to severe cancer pain.
Clincial Studies about Tapentadol 100 mg
Animal and human-based clinical studies have shown that Tapentadol can be used in various pain conditions, including nociceptive, neuropathic, post-surgical, and chemo-induced pain. Pain is a highly unpleasant sensation caused by injury or disease that impacts the subject’s comfort levels and psychological states to a significant extent. While acute pain is uncomfortable, it lasts for a short period, unlike chronic pain, which increases the risk of anxiety, depression, and substance abuse because of its long-standing effects. Tapentadol is helpful in moderate to severe acute and long-term chronic pain and is well tolerated by patients. Conditions of osteoarthritic pain have been observed to respond exceptionally well to Tapentadol compared to analgesics like Oxycodone or Ibuprofen.
In a study including Tapentadol 50 and 75 mg and Oxycodone 10 mg for bunionectomy, Tapentadol showed an improved analgesic effect and was well tolerated. Studies on Post Surgical dental pain in patients undergoing third molar extraction have shown single doses of Tapentadol to have a higher effectiveness and safety profile than Morphine, an analgesic that is highly potent but which comes with the risk of abuse and dependence.
Even patients with an end-stage degenerative joint disease with chronic inflammatory pain and long-term back pain have observed similar results with Tapentadol and Oxycodone but with fewer side effects and superior gastronomic tolerability from using Tapentadol.
Phase three trials in patients with painful diabetic neuropathy have shown significant clinical improvement and further proved the efficacy of Tapentadol for neuropathic pain.
How long should you take Tapentadol 100 MG for
The duration of usage of Tapentadol depends on the pain condition for which you have been advised, the medication, the intensity of pain, and the treatment plan of the medical practitioner in charge. However, you should not use it indefinitely as it can increase tolerance and worsen withdrawal symptoms. Usually, Tapentadol 100MG tablets must be used every 4-6 hours with or without food. But you can take the second dose within an hour of use if the physician advises in severe pain conditions.
Tapentaold online Dosage
For Tapentadol, the recommended dose is 50mg to 200mg, taken as required. As Tapentadol may be habit-forming, only take Tapentadol as prescribed by your Pain Clinic or out-of-hours services. The dosage can be increased by 25mg up to 200mg taken as required to a maximum of 400mg per day if there is insufficient pain relief. In some patients, escalating over 4hrs of steady state is required to achieve higher analgesic doses in recommended patient dose range.
For other patients, pain relief is best achieved with Tapentadol given twice daily with a total dose not exceeding 400mg daily. The daily dose should not be exceeded for more than 12 days unless in exceptional circumstances and under careful supervision. Treatment of chronic pain with opioids should not exceed 12 weeks, and continuous therapy should not be initiated before considering an alternative treatment strategy.
What is the difference between Tapentadol IR and SR?
Tapentadol IR or Immediate Release is used in patients with acute pain conditions in recommended 50-100 mg doses every four hours. It is indicated in patients not responding to conventional opioids or in elderly patients with gastrointestinal side effects. Tapentadol SR or Slow Release is used in patients with chronic pain of a moderate to severe intensity not responding to non-narcotic traditional analgesics like Etodolac or Carprofen. Trauma-induced pain like fractures and patients with a tendency to opioid side-effects are usually advised Tapentadol SR formulations.
Tapentadol vs. Tramadol : which is better?
Tapentadol and Tramadol have similar chemical structures and are considered effective first-line analgesics. But Tapentadol has shown better analgesia because of its dual mechanism of action with an improved side-effect profile. An important advantage of Tapentadol is that it is not a pro-drug like Tramadol ( medications that turn into an active form on entering the body because it has an earlier onset period and lasts for a long time.
Better analgesia with Tapentadol
Inhibition of NA revptake and week
Inhibition of revptake of
| Improve side effect profile of |
| Prodrug Active metabolite is |
Early onset of action with tapentadol
Onset of Action
Within 60 Min
Early onset of action with tapentadol
Lack Of CYP 450 interaction
Metabolised by CYP 450 enzymes
| Minimum risk of adverse drug |
interaction with tapentadol
Lack Of CYP interaction
| Primarily metabolised by CYP 450 isoenzyme |
2D6 poor metabolised may not get satisfactory
analgesia with usval does of tramadol
| No inter-individual variation with|
Conversely, Tapentadol can only be administered orally, whereas Tramadol can be administered orally, as an epidural, intramuscularly, and as a suppository.
Side Effect of Tapentadol 100 mg in the UK
Tapentadol should be used as part of a complete pain management programme that includes monitoring [special conditions]. If your doctor has prescribed Tapentadol, it is very important that you follow the programme set out for you even if you feel well. The risk of addiction is high if Tapentadol is misused. Misuse includes taking Tapentadol with benzodiazepines and other non-opioid medications or alcohol. Misuse also includes using Tapentadol to achieve a feeling of euphoria.
The possible effects of Tapentadol when taken by mouth or injected into your vein include:
→ Feeling sick
Symptoms of Tapentadol overdose include slow and shallow breathing, drowsiness, confusion, pinpoint pupils, very small pupils, weak pulse, low blood pressure, muscle spasms, seizure and coma.
Withdrawal symptoms may occur in patients who abruptly discontinue Tapentadol after prolonged use, usually after several months or longer, but may occur following a few weeks of use.
Do I need a prescription to buy Tapentadol?
Tapentadol is a Schedule II medication with a moderate degree of abuse that cannot be obtained over the counter but needs a prescription. The US Drug Enforcement Administration (DEA) has classified Tapentadol as a controlled substance due to its risk of inducing opioid addiction and misuse. You need a prescription to obtain Tapentadol from registered pharmacies dispensing the medicine. Alternatively, you can get it from selected GP clinics with a retail outlet for dispensing Tapentadol.
How can I buy Tapentadol in UK?
Tapentadol is available under the trade name of Palexia in the UK and has a controlled status. You will require a physician’s prescription with instructions on the strength, dose, and duration of use of Tapentadol to avail of the medication or its refills. Additionally, your physician must specify the Tapentadol you need ( Immediate Release, Slow Release) as a monotherapy or combination medicine.
Is it safe to buy Tapentadol online in UK?
Online portals are an effective way of obtaining Tapentadol in the UK, provided you purchase from a safe site with a reputation for delivering authentic medicine. While buying Tapentadol online
- Check the registration details of the site before ordering
- Be specific about the strength and formulation of Tapentadol that you are ordering
- Ensure that the website has a valid customer care service and an excellent online reputation
Is Tapentadol high-risk?
Even if the side effects of Tapentadol are milder than other opioids, used indiscriminately, it can result in several side effects and, at times, can be life-threatening.
Tapentadol has a moderate abuse and addiction potential and is contraindicated in people using MAO inhibitors or those with heart disease. Tapentadol misuse can even lead to serotonin syndrome and progress to cardiac arrhythmia if not treated timely.
Pregnant women, those with kidney or liver problems, or those allergic to its ingredients should refrain from using it.
Can I just stop taking Tapentadol?
Suddenly stopping Tapentadol can increase the severity of withdrawal symptoms and result in side effects like nausea, vomiting, joint pain, anxiety, fever, or chills. The correct way is to taper the dose or gradually decrease the strength and dosage you have been using before discontinuing it.Tapentadol use can make you feel lightheaded and sleepy. You should not drive or operate heavy machinery after using it for safety reasons.
Inform the Physician or Doctor at the clinic if:
– you are allergic to Tapentadol or any of its ingredients
– you have a history of severe allergies, including an allergy to Tapentadol. Tell your doctor if you have ever had allergic reactions after using painkillers.
– you think you might be pregnant or are planning to get pregnant
– You are breastfeeding
– You are known to have the rare hereditary problems of galactose intolerance (the Lapp lactase deficiency), glucose-galactose malabsorption or sucrose-isomaltase deficiency.
– You have a history of mental illness or drug or alcohol addiction
– You are currently taking monoamine oxidase inhibitors or within 14 days of such therapy or any other antidepressant.
– You have any of the following conditions: bowel strictures, breathing disorders, liver or kidney disease, epilepsy or seizure disorders, gallbladder disease or problems with your pancreas. The most common side effects are nausea, dizziness and drowsiness which may limit your ability to drive or operate machinery and can also make you more prone to accidents. Other side effects include constipation, vomiting, itching sensation in the palms/fingers/toes, abdominal